Ultrastructural identification of non-adrenergic, non-cholinergic nerves in the rat anococcygeus muscle

I. L. Gibbins, C. J. Haller

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The innervation of the rat anococcygeus muscle has been investigated ultrastructurally following fixation with a modified chromaffin reaction for the demonstration of biogenic amines (Tranzer and Richards, 1976). Three types of nerve profiles were revealed: (1) 60-70 % of the profiles are adrenergic; (2) less than 5% of the profiles appear to be cholinergic; (3) up to 40% of the profiles are distinguished by the presence of a characteristically high proportion of electron-opaque, chromaffin-negative vesicles, 85-110nm in diameter. This third type of profile was not affected by 6-OHDA, and is considered to represent the non-adrenergic, non-cholinergic inhibitory innervation of this tissue. Because of the morphological similarity of this nerve type, apart from the smaller vesicle size, to classical peptidergic nerve endings, they have been termed "small p-type" (sp-type). These results are discussed in relation to a previous report describing only two types of nerve profiles in this tissue (Gillespie and Lüllmann-Rauch, 1974).

Original languageEnglish
Pages (from-to)257-271
Number of pages15
JournalCell and Tissue Research
Volume200
Issue number2
DOIs
Publication statusPublished - Aug 1979
Externally publishedYes

Keywords

  • Anococcygeus muscle
  • Innervation
  • P-type nerves
  • Purinergic nerves
  • Ultrastructure

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