Unconventional Vaccines: Progress and Challenges

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    Abstract

    When vaccines are mentioned most people think of immunization against childhood infectious diseases. However, in recent years the uses to which vaccines are being put has dramatically expanded beyond traditional infectious disease applications. Vaccines currently in preclinical and clinical development target prevention or treatment of a wide range of non-infectious diseases including cancer, allergy, asthma, diabetes, rheumatoid arthritis, lupus, hypertension, heart disease, obesity, Alzheimer's disease, Parkison's disease and even nicotine and cocaine addiction. For the most part such vaccines aim to induce neutralizing antibodies against foreign or self-antigens, thereby blocking their activity and ability to induce disease. This commentary reviews key clinical advances in the area of unconventional vaccines and identifies some of the key challenges that need to be overcome in order for unconventional vaccines to move forward to medical and commercial success.

    Original languageEnglish
    Pages (from-to)1-4
    Number of pages4
    JournalJournal of Vaccines and Vaccination
    Volume4
    Issue number4
    DOIs
    Publication statusPublished - May 2013

    Bibliographical note

    Copyright:
    Copyright 2018 Elsevier B.V., All rights reserved.

    Keywords

    • Immunogenicity
    • Infectious diseases
    • Vaccines

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