Untying the gordian knot of cytokinesis: Role of small G proteins and their regulators

Sergei N. Prokopenko, Robert B. Saint, Hugo J. Bellen

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Ability to divide is one of the basic properties of a cell. In metazoans, where cells divide in a context of germ layers, tissues, and organs, cell proliferation must be coordinated with differentiation to prevent developmental abnormalities. Genetic analyses in simple model systems (yeast, slime mold, fruit fly) have demonstrated that defects in either karyokinesis, or nuclear division (e.g., mutations that affect cell cycle checkpoints, mitotic chromosome condensation and segregation, etc.), or cytokinesis (Fig. 1), both may delay or block development.
Original languageEnglish
Pages (from-to)843-848
Number of pages6
JournalJournal of Cell Biology
Volume148
Issue number5
Publication statusPublished - 2000

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