TY - JOUR
T1 - Unusual organelles in an epithelioid angiosarcoma
AU - Eyden, Brian
AU - Prescott, Richard
AU - Curry, Alan
AU - Haboubi, Najib
AU - Mackay, Bruce
AU - Ordoñez, Nelson
AU - Stirling, John W.
AU - Henderson, Douglas W.
AU - Papadimitriou, John M.
PY - 1993
Y1 - 1993
N2 - We recently encountered unusual organelles in a tumor from a 75-year-old white British female presenting with a scalp lesion which histologically was a poorly differentiated malignant neoplasm (Fig. 1). On the basis of histology and immunohistochemistry [positive staining for factor Vlll-related antigen (Fig. 2), JC70A (CD31),1 and Ulex europaeus agglutinin 1] the tumor was diagnosed as an epithelioid angiosarcoma. An unexpected finding was that some unambiguous tumor cells were positive for S100 protein. Occasional S100 protein-positive dendritic cells, interpreted as reactive Langerhans cells, were also present. To confirm a confidently held diagnosis, but one which was nevertheless uncertain because of the S100 protein staining, electron microscopy was conducted. Not unexpectedly, Weibel-Palade bodies were not identified,2 but the rough endoplasmic reticulum, polyribosomes, aggregates of haphazardly arranged intermediate filaments, and a well developed lamina were seen as being consistent with epithelioid angiosarcoma.
AB - We recently encountered unusual organelles in a tumor from a 75-year-old white British female presenting with a scalp lesion which histologically was a poorly differentiated malignant neoplasm (Fig. 1). On the basis of histology and immunohistochemistry [positive staining for factor Vlll-related antigen (Fig. 2), JC70A (CD31),1 and Ulex europaeus agglutinin 1] the tumor was diagnosed as an epithelioid angiosarcoma. An unexpected finding was that some unambiguous tumor cells were positive for S100 protein. Occasional S100 protein-positive dendritic cells, interpreted as reactive Langerhans cells, were also present. To confirm a confidently held diagnosis, but one which was nevertheless uncertain because of the S100 protein staining, electron microscopy was conducted. Not unexpectedly, Weibel-Palade bodies were not identified,2 but the rough endoplasmic reticulum, polyribosomes, aggregates of haphazardly arranged intermediate filaments, and a well developed lamina were seen as being consistent with epithelioid angiosarcoma.
UR - http://www.scopus.com/inward/record.url?scp=84907105708&partnerID=8YFLogxK
U2 - 10.3109/01913129309084035
DO - 10.3109/01913129309084035
M3 - Article
C2 - 8316963
AN - SCOPUS:0027563644
SN - 0191-3123
VL - 17
SP - 153
EP - 159
JO - ULTRASTRUCTURAL PATHOLOGY
JF - ULTRASTRUCTURAL PATHOLOGY
IS - 2
ER -