Update on optimal treatment for metastatic colorectal cancer from the AGITG expert meeting: ESMO congress 2019

David K. Lau, Matthew Burge, Amitesh Roy, Ian Chau, Daniel G. Haller, Jeremy D. Shapiro, Marc Peeters, Nick Pavlakis, Christos S. Karapetis, Niall C. Tebbutt, Eva Segelov, Timothy J. Price

    Research output: Contribution to journalReview article

    Abstract


    Introduction: Outcomes in metastatic colorectal cancer are improving, due to the tailoring of therapy enabled by better understanding of clinical behavior according to molecular subtype.

    Areas covered: A review of the literature and recent conference presentations was undertaken on the topic of systemic treatment of metastatic colorectal cancer. This review summarizes expert discussion of the current evidence for therapies in metastatic colorectal cancer (mCRC) based on molecular subgrouping.

    Expert opinion: EGFR-targeted and VEGF-targeted antibodies are now routinely incorporated into treatment strategies for mCRC. EGFR-targeted antibodies are restricted to patients with extended RAS wild-type profiles, with evidence that they should be further restricted to patients with left-sided tumors. Clinically distinct treatment pathways based on tumor RAS, BRAF, HER2 and MMR status, are now clinically applicable. Evidence suggests therapy for additional subgroups will soon be defined; the most advanced being for patients with KRAS G12 C mutation and gene TRK fusion defects.

    Original languageEnglish
    Pages (from-to)251-270
    Number of pages20
    JournalExpert Review of Anticancer Therapy
    Volume20
    Issue number4
    DOIs
    Publication statusPublished - 6 Apr 2020

    Keywords

    • BRAF
    • chemotherapy
    • Colorectal
    • consensus
    • metastatic
    • MSI
    • RAS

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  • Cite this

    Lau, D. K., Burge, M., Roy, A., Chau, I., Haller, D. G., Shapiro, J. D., Peeters, M., Pavlakis, N., Karapetis, C. S., Tebbutt, N. C., Segelov, E., & Price, T. J. (2020). Update on optimal treatment for metastatic colorectal cancer from the AGITG expert meeting: ESMO congress 2019. Expert Review of Anticancer Therapy, 20(4), 251-270. https://doi.org/10.1080/14737140.2020.1744439