TY - JOUR
T1 - Urinary metal and polycyclic aromatic hydrocarbon biomarkers in boilermakers exposed to metal fume and residual oil fly ash
AU - Mukherjee, Sutapa
AU - Rodrigues, Ema
AU - Aeschliman, David B.
AU - Houk, R. S.
AU - Palmer, Lyle J.
AU - Woodin, Mark A.
AU - Weker, Robert
AU - Christiani, David C.
PY - 2005/6/1
Y1 - 2005/6/1
N2 - Background: Boilermakers are occupationally exposed to known carcinogens. Methods: The association of urinary 1-hydroxy-pyrene (1-OHP), a biomarker of polycyclic aromatic hydrocarbon (PAH) exposure, with biomarkers of metal exposure (vanadium, chromium, manganese, nickel, copper, and lead) in boilermakers exposed to metal fume from welding and dust particulates from residual oil fly ash (ROFA) was examined. A repeated measures cohort study was conducted during the overhaul of an oil-fired boiler. Twice-daily urine samples were obtained for 5 days and analyzed for cotinine, 1-OHP, and metals. Generalized estimating equations (GEE) were used to model the multivariate relationship of 1-OHP to the explanatory variables. Results: Metal and 1-OHP levels were determined for 165 urine samples from 20 boilermakers and these levels increased during the workweek. However, the 1-OHP level was not significantly associated with any individual metal level at any time point. Conclusion: This suggests that boilermakers were occupationally exposed to PAH and metals, but 1-OHP as a PAH biomarker was unable to serve as a surrogate marker of metal exposure for the metals measured in this study.
AB - Background: Boilermakers are occupationally exposed to known carcinogens. Methods: The association of urinary 1-hydroxy-pyrene (1-OHP), a biomarker of polycyclic aromatic hydrocarbon (PAH) exposure, with biomarkers of metal exposure (vanadium, chromium, manganese, nickel, copper, and lead) in boilermakers exposed to metal fume from welding and dust particulates from residual oil fly ash (ROFA) was examined. A repeated measures cohort study was conducted during the overhaul of an oil-fired boiler. Twice-daily urine samples were obtained for 5 days and analyzed for cotinine, 1-OHP, and metals. Generalized estimating equations (GEE) were used to model the multivariate relationship of 1-OHP to the explanatory variables. Results: Metal and 1-OHP levels were determined for 165 urine samples from 20 boilermakers and these levels increased during the workweek. However, the 1-OHP level was not significantly associated with any individual metal level at any time point. Conclusion: This suggests that boilermakers were occupationally exposed to PAH and metals, but 1-OHP as a PAH biomarker was unable to serve as a surrogate marker of metal exposure for the metals measured in this study.
KW - Biomarkers
KW - Carcinogens
KW - Occupational health
KW - Particulates
UR - http://www.scopus.com/inward/record.url?scp=20444389827&partnerID=8YFLogxK
U2 - 10.1002/ajim.20161
DO - 10.1002/ajim.20161
M3 - Article
C2 - 15898092
AN - SCOPUS:20444389827
VL - 47
SP - 484
EP - 493
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
SN - 0271-3586
IS - 6
ER -