Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

Ben J. Marais; Elaine Cheong; Shelanah Fernando; Santhosh Daniel; Matthew R. Watts; Lucinda J. Berglund; Simone E. Barry; George Kotsiou; Alex P. Headley; Richard A. Stapledon

doi:10.1093/ofid/ofaa604

Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

Ben J. Marais, Elaine Cheong, Shelanah Fernando, Santhosh Daniel, Matthew R. Watts, Lucinda J. Berglund, Simone E. Barry, George Kotsiou, Alex P. Headley, Richard A. Stapledon

College of Medicine and Public Health

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Abstract

We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.

Original language	English
Article number	ofaa604
Number of pages	5
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	1
Early online date	28 Dec 2020
DOIs	https://doi.org/10.1093/ofid/ofaa604
Publication status	Published - 1 Jan 2021

Keywords

Infliximab
Paradoxical reactions
Tuberculous meningitis

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10.1093/ofid/ofaa604Licence: CC BY-NC-ND

Final published versionFinal published version, 473 KBLicence: CC BY-NC-ND

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abstract = "We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.",

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AU - Daniel, Santhosh

AU - Watts, Matthew R.

AU - Berglund, Lucinda J.

AU - Barry, Simone E.

AU - Kotsiou, George

AU - Headley, Alex P.

AU - Stapledon, Richard A.

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Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

Abstract

Keywords

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