Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

Ben J. Marais, Elaine Cheong, Shelanah Fernando, Santhosh Daniel, Matthew R. Watts, Lucinda J. Berglund, Simone E. Barry, George Kotsiou, Alex P. Headley, Richard A. Stapledon

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
1 Downloads (Pure)


We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.

Original languageEnglish
Article numberofaa604
Number of pages5
JournalOpen Forum Infectious Diseases
Issue number1
Early online date28 Dec 2020
Publication statusPublished - 1 Jan 2021


  • Infliximab
  • Paradoxical reactions
  • Tuberculous meningitis


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