Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

Ben J. Marais, Elaine Cheong, Shelanah Fernando, Santhosh Daniel, Matthew R. Watts, Lucinda J. Berglund, Simone E. Barry, George Kotsiou, Alex P. Headley, Richard A. Stapledon

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
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Abstract

We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.

Original languageEnglish
Article numberofaa604
Number of pages5
JournalOpen Forum Infectious Diseases
Volume8
Issue number1
Early online date28 Dec 2020
DOIs
Publication statusPublished - 1 Jan 2021

Keywords

  • Infliximab
  • Paradoxical reactions
  • Tuberculous meningitis

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