Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

Ben J. Marais; Elaine Cheong; Shelanah Fernando; Santhosh Daniel; Matthew R. Watts; Lucinda J. Berglund; Simone E. Barry; George Kotsiou; Alex P. Headley; Richard A. Stapledon

doi:10.1093/ofid/ofaa604

Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

Ben J. Marais, Elaine Cheong, Shelanah Fernando, Santhosh Daniel, Matthew R. Watts, Lucinda J. Berglund, Simone E. Barry, George Kotsiou, Alex P. Headley, Richard A. Stapledon

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

81 Downloads (Pure)

Abstract

We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.

Original language	English
Article number	ofaa604
Number of pages	5
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	1
Early online date	28 Dec 2020
DOIs	https://doi.org/10.1093/ofid/ofaa604
Publication status	Published - 1 Jan 2021

Keywords

Infliximab
Paradoxical reactions
Tuberculous meningitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/ofid/ofaa604Licence: CC BY-NC-ND

Final published versionFinal published version, 473 KBLicence: CC BY-NC-ND

Cite this

@article{b1d552609c1f41c0b21b5c7c9c4d6f68,

title = "Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions",

abstract = "We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.",

keywords = "Infliximab, Paradoxical reactions, Tuberculous meningitis",

author = "Marais, {Ben J.} and Elaine Cheong and Shelanah Fernando and Santhosh Daniel and Watts, {Matthew R.} and Berglund, {Lucinda J.} and Barry, {Simone E.} and George Kotsiou and Headley, {Alex P.} and Stapledon, {Richard A.}",

year = "2021",

month = jan,

day = "1",

doi = "10.1093/ofid/ofaa604",

language = "English",

volume = "8",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Infectious Diseases Society of America",

number = "1",

}

TY - JOUR

T1 - Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

AU - Marais, Ben J.

AU - Cheong, Elaine

AU - Fernando, Shelanah

AU - Daniel, Santhosh

AU - Watts, Matthew R.

AU - Berglund, Lucinda J.

AU - Barry, Simone E.

AU - Kotsiou, George

AU - Headley, Alex P.

AU - Stapledon, Richard A.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.

AB - We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.

KW - Infliximab

KW - Paradoxical reactions

KW - Tuberculous meningitis

UR - http://www.scopus.com/inward/record.url?scp=85114215885&partnerID=8YFLogxK

U2 - 10.1093/ofid/ofaa604

DO - 10.1093/ofid/ofaa604

M3 - Article

SN - 2328-8957

VL - 8

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 1

M1 - ofaa604

ER -

Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this