Use of intravitreal rituximab for treatment of vitreoretinal lymphoma.

Kelly Larkin, Ujwala Saboo, Grant Comer, Farzin Forooghian, F MacKensen, Pauline Merrill, H Sen, Arun Singh, Rohan Essex, Stewart Lake, Lyndell Lim, Daniel Vasconcelos-Santos, C. Foster, David Wilson, Justine Smith

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    33 Citations (Scopus)

    Abstract

    Aim: Vitreoretinal lymphoma is a diffuse large B cell non-Hodgkin lymphoma. Targeting malignant cells with rituximab is being used increasingly as local chemotherapy, but information on this treatment is scant. We aimed to describe current therapeutic approaches, as well as responses to and complications of, intravitreal rituximab in patients with vitreoretinal lymphoma. Methods: Clinical data were collected in a standardised manner retrospectively on patients with vitreoretinal lymphoma treated with intravitreal rituximab. Results: 48 eyes (34 patients) with vitreoretinal lymphoma were treated with a median of 3.5 intravitreal injections of rituximab (1 mg/0.1 mL) for new diagnosis (68.8%), progressive disease (29.9%) and maintenance therapy (2.1%). Intravitreal rituximab±methotrexate was the sole treatment in 19 eyes (39.6%). 31 eyes (64.6%) eyes achieved complete remission, after a median of 3 injections; 7 of these eyes developed recurrent disease. 11 eyes (22.9%) achieved partial remission. Although rituximab may have contributed to complications reported in 12 eyes (25.0%), a 2-line loss of Snellen visual acuity occurred in only 2 of those eyes (4.2%). Conclusions: Approaches in rituximab-based intravitreal chemotherapy vary widely, but our findings suggest that this treatment may be safe and effective in inducing remission in a majority of eyes with vitreoretinal lymphoma.

    Original languageEnglish
    Pages (from-to)99-103
    Number of pages5
    JournalBritish Journal of Ophthalmology
    Volume98
    Issue number1
    DOIs
    Publication statusPublished - 2014

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    Larkin, K., Saboo, U., Comer, G., Forooghian, F., MacKensen, F., Merrill, P., Sen, H., Singh, A., Essex, R., Lake, S., Lim, L., Vasconcelos-Santos, D., Foster, C., Wilson, D., & Smith, J. (2014). Use of intravitreal rituximab for treatment of vitreoretinal lymphoma. British Journal of Ophthalmology, 98(1), 99-103. https://doi.org/10.1136/bjophthalmol-2013-304043