Use of the Australian Childhood Immunisation Register for vaccine safety data linkage

Michael Gold, Sarah Dugdale, Richard Woodman, Kieran McCaul

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)

    Abstract

    We linked the Australian Childhood Immunisation Register (ACIR) to South Australian (SA) hospital outcome data in order to evaluate the association between Measles Mumps and Rubella (MMR) and Diphtheria Tetanus Pertussis (DTP) vaccines and convulsions. Linkage occurred using probabilistic matching and data was analysed using the self-controlled case series methodology. An increase in febrile convulsions 6-11 days post-MMR vaccination was demonstrated which equates to a vaccine-attributable risk of 1 convulsion per 6753 vaccines. This study confirms the known association between MMR vaccination and febrile convulsions and in doing so demonstrates the feasibility of using the ACIR for data linkage and vaccine safety surveillance.

    Original languageEnglish
    Pages (from-to)4308-4311
    Number of pages4
    JournalVaccine
    Volume28
    Issue number26
    DOIs
    Publication statusPublished - 11 Jun 2010

    Keywords

    • Australian Childhood Immunisation Record
    • Data linkage
    • Vaccine safety

    Fingerprint Dive into the research topics of 'Use of the Australian Childhood Immunisation Register for vaccine safety data linkage'. Together they form a unique fingerprint.

    Cite this