TY - JOUR
T1 - Using the multidimensional prognostic index to predict clinical outcomes of hospitalized older persons
T2 - A prospective, multicenter, international study
AU - MPI_AGE Investigators
AU - Pilotto, Alberto
AU - Veronese, Nicola
AU - Daragjati, Julia
AU - Cruz-Jentoft, Alfonso J.
AU - Polidori, Maria Cristina
AU - Mattace-Raso, Francesco
AU - Paccalin, Marc
AU - Topinkova, Eva
AU - Siri, Giacomo
AU - Greco, Antonio
AU - Mangoni, Arduino A.
AU - Maggi, Stefania
AU - Ferrucci, Luigi
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Background: Multidimensional Prognostic Index (MPI) is useful as a prognostic tool in hospitalized older patients, but our knowledge is derived from retrospective studies. We therefore aimed to evaluate in a multicenter, longitudinal, cohort study whether the MPI at hospital admission is useful to identify groups with different mortality risk and whether MPI at discharge may predict institutionalization, rehospitalization, and use of home care services during 12 months. Methods: This longitudinal study, carried out between February 2015 and August 2017, included nine public hospitals in Europe and Australia. A standardized comprehensive geriatric assessment including information on functional, nutritional, cognitive status, risk of pressure sores, comorbidities, medications, and cohabitation status was used to calculate the MPI and to categorize participants in low, moderate, and severe risk of mortality. Data regarding mortality, institutionalization, rehospitalization, and use of home care services were recorded through administrative information. Results: Altogether, 1,140 hospitalized patients (mean age 84.1 years, women = 60.8%) were included. In the multivariable analysis, compared to patients with low risk group at admission, patients in moderate (odds ratio [OR] = 3.32; 95% CI: 1.79–6.17; p < .001) and severe risk (OR = 10.72, 95% CI: 5.70–20.18, p < .0001) groups were at higher risk of overall mortality. Among the 984 older patients with follow-up data available, those in the severe-risk group experienced a higher risk of overall mortality, institutionalization, rehospitalization, and access to home care services. Conclusions: In this cohort of hospitalized older adults, higher MPI values are associated with higher mortality and other negative outcomes. Multidimensional assessment of older people admitted to hospital may facilitate appropriate clinical and postdischarge management.
AB - Background: Multidimensional Prognostic Index (MPI) is useful as a prognostic tool in hospitalized older patients, but our knowledge is derived from retrospective studies. We therefore aimed to evaluate in a multicenter, longitudinal, cohort study whether the MPI at hospital admission is useful to identify groups with different mortality risk and whether MPI at discharge may predict institutionalization, rehospitalization, and use of home care services during 12 months. Methods: This longitudinal study, carried out between February 2015 and August 2017, included nine public hospitals in Europe and Australia. A standardized comprehensive geriatric assessment including information on functional, nutritional, cognitive status, risk of pressure sores, comorbidities, medications, and cohabitation status was used to calculate the MPI and to categorize participants in low, moderate, and severe risk of mortality. Data regarding mortality, institutionalization, rehospitalization, and use of home care services were recorded through administrative information. Results: Altogether, 1,140 hospitalized patients (mean age 84.1 years, women = 60.8%) were included. In the multivariable analysis, compared to patients with low risk group at admission, patients in moderate (odds ratio [OR] = 3.32; 95% CI: 1.79–6.17; p < .001) and severe risk (OR = 10.72, 95% CI: 5.70–20.18, p < .0001) groups were at higher risk of overall mortality. Among the 984 older patients with follow-up data available, those in the severe-risk group experienced a higher risk of overall mortality, institutionalization, rehospitalization, and access to home care services. Conclusions: In this cohort of hospitalized older adults, higher MPI values are associated with higher mortality and other negative outcomes. Multidimensional assessment of older people admitted to hospital may facilitate appropriate clinical and postdischarge management.
KW - Aged
KW - Cohort study
KW - Hospital
KW - Multidimensional Prognostic Index
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=85072316874&partnerID=8YFLogxK
U2 - 10.1093/gerona/gly239
DO - 10.1093/gerona/gly239
M3 - Article
C2 - 30329033
AN - SCOPUS:85072316874
VL - 74
SP - 1643
EP - 1649
JO - Journals of Gerontology Series A-Biological Sciences and Medical Sciences
JF - Journals of Gerontology Series A-Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 10
ER -