Utility of four sarcopenia criteria for the prediction of falls-related hospitalization in older Australian women

M. Sim; R. L. Prince; D. Scott; R. M. Daly; G. Duque; C. A. Inderjeeth; K. Zhu; R. J. Woodman; J. M. Hodgson; J. R. Lewis

doi:10.1007/s00198-018-4755-7

Utility of four sarcopenia criteria for the prediction of falls-related hospitalization in older Australian women

M. Sim, R. L. Prince, D. Scott, R. M. Daly, G. Duque, C. A. Inderjeeth, K. Zhu, R. J. Woodman, J. M. Hodgson, J. R. Lewis

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Summary: Numerous sarcopenia definitions are not associated with increased falls-related hospitalization risk over 5 years to 9.5 years in older community-dwelling Australian women. Measures of muscle strength and physical function, but not appendicular lean mass (measured by dual-energy X-ray absorptiometry) may help discriminate the risk of falls-related hospitalization.

Introduction: The aim of this prospective, population-based cohort study of 903 Caucasian-Australian women (mean age 79.9 ± 2.6 years) was to compare the clinical utility of four sarcopenia definitions for the prediction of falls-related hospitalization over 9.5 years.

Methods: The four definitions were the United States Foundation for the National Institutes of Health (FNIH), the European Working Group on Sarcopenia in Older People (EWGSOP), and modified FNIH (AUS-POP _F ) and EWGSOP (AUS-POP _E ) definitions using Australian population-specific cut points (< 2 SD below the mean of young healthy Australian women). Components of sarcopenia including muscle strength, physical function, and appendicular lean mass (ALM) were quantified using hand grip strength, timed-up-and-go (TUG), and dual-energy X-ray absorptiometry (DXA), respectively. Incident 9.5-year falls-related hospitalization were captured by linked data.

Results: Baseline prevalence of sarcopenia according to FNIH (9.4%), EWGSOP (24.1%), AUS-POP _F (12.0%), and AUS-POP _E (10.7%) differed substantially. Sarcopenia did not increase the relative hazard ratio (HR) for falls-related hospitalization before or after adjustment for age (aHR): FNIH aHR 1.00 95%CI (0.69–1.47), EWGSOP aHR 1.20 95%CI (0.93–1.54), AUS-POP _F aHR 0.96 95%CI (0.68–1.35), and AUS-POP _E aHR 1.33 95%CI (0.94–1.88). When examining individual components of sarcopenia, only muscle strength and physical function but not ALM (adjusted for height ² or BMI) were associated with falls-related hospitalization.

Conclusion: Current definitions of sarcopenia were not associated with falls-related hospitalization risk in this cohort of community-dwelling older Australian women. Finally, measures of muscle strength and physical function, but not ALM (measured by DXA) may help discriminate the risk of falls-related hospitalization.

Original language	English
Pages (from-to)	167-176
Number of pages	10
Journal	Osteoporosis International
Volume	30
DOIs	https://doi.org/10.1007/s00198-018-4755-7
Publication status	Published - 18 Jan 2019

Keywords

Falls-related hospitalization
Geriatrics
Muscle mass
Muscle strength
Physical function

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{352c19f5ae0d4416a22b5a5d9d136811,

title = "Utility of four sarcopenia criteria for the prediction of falls-related hospitalization in older Australian women",

abstract = " Summary: Numerous sarcopenia definitions are not associated with increased falls-related hospitalization risk over 5 years to 9.5 years in older community-dwelling Australian women. Measures of muscle strength and physical function, but not appendicular lean mass (measured by dual-energy X-ray absorptiometry) may help discriminate the risk of falls-related hospitalization. Introduction: The aim of this prospective, population-based cohort study of 903 Caucasian-Australian women (mean age 79.9 ± 2.6 years) was to compare the clinical utility of four sarcopenia definitions for the prediction of falls-related hospitalization over 9.5 years. Methods: The four definitions were the United States Foundation for the National Institutes of Health (FNIH), the European Working Group on Sarcopenia in Older People (EWGSOP), and modified FNIH (AUS-POP F ) and EWGSOP (AUS-POP E ) definitions using Australian population-specific cut points (< 2 SD below the mean of young healthy Australian women). Components of sarcopenia including muscle strength, physical function, and appendicular lean mass (ALM) were quantified using hand grip strength, timed-up-and-go (TUG), and dual-energy X-ray absorptiometry (DXA), respectively. Incident 9.5-year falls-related hospitalization were captured by linked data. Results: Baseline prevalence of sarcopenia according to FNIH (9.4%), EWGSOP (24.1%), AUS-POP F (12.0%), and AUS-POP E (10.7%) differed substantially. Sarcopenia did not increase the relative hazard ratio (HR) for falls-related hospitalization before or after adjustment for age (aHR): FNIH aHR 1.00 95%CI (0.69–1.47), EWGSOP aHR 1.20 95%CI (0.93–1.54), AUS-POP F aHR 0.96 95%CI (0.68–1.35), and AUS-POP E aHR 1.33 95%CI (0.94–1.88). When examining individual components of sarcopenia, only muscle strength and physical function but not ALM (adjusted for height 2 or BMI) were associated with falls-related hospitalization. Conclusion: Current definitions of sarcopenia were not associated with falls-related hospitalization risk in this cohort of community-dwelling older Australian women. Finally, measures of muscle strength and physical function, but not ALM (measured by DXA) may help discriminate the risk of falls-related hospitalization. ",

keywords = "Falls-related hospitalization, Geriatrics, Muscle mass, Muscle strength, Physical function",

author = "M. Sim and Prince, {R. L.} and D. Scott and Daly, {R. M.} and G. Duque and Inderjeeth, {C. A.} and K. Zhu and Woodman, {R. J.} and Hodgson, {J. M.} and Lewis, {J. R.}",

year = "2019",

month = jan,

day = "18",

doi = "10.1007/s00198-018-4755-7",

language = "English",

volume = "30",

pages = "167--176",

journal = "Osteoporosis International",

issn = "0937-941X",

publisher = "Springer UK",

}

TY - JOUR

T1 - Utility of four sarcopenia criteria for the prediction of falls-related hospitalization in older Australian women

AU - Sim, M.

AU - Prince, R. L.

AU - Scott, D.

AU - Daly, R. M.

AU - Duque, G.

AU - Inderjeeth, C. A.

AU - Zhu, K.

AU - Woodman, R. J.

AU - Hodgson, J. M.

AU - Lewis, J. R.

PY - 2019/1/18

Y1 - 2019/1/18

N2 - Summary: Numerous sarcopenia definitions are not associated with increased falls-related hospitalization risk over 5 years to 9.5 years in older community-dwelling Australian women. Measures of muscle strength and physical function, but not appendicular lean mass (measured by dual-energy X-ray absorptiometry) may help discriminate the risk of falls-related hospitalization. Introduction: The aim of this prospective, population-based cohort study of 903 Caucasian-Australian women (mean age 79.9 ± 2.6 years) was to compare the clinical utility of four sarcopenia definitions for the prediction of falls-related hospitalization over 9.5 years. Methods: The four definitions were the United States Foundation for the National Institutes of Health (FNIH), the European Working Group on Sarcopenia in Older People (EWGSOP), and modified FNIH (AUS-POP F ) and EWGSOP (AUS-POP E ) definitions using Australian population-specific cut points (< 2 SD below the mean of young healthy Australian women). Components of sarcopenia including muscle strength, physical function, and appendicular lean mass (ALM) were quantified using hand grip strength, timed-up-and-go (TUG), and dual-energy X-ray absorptiometry (DXA), respectively. Incident 9.5-year falls-related hospitalization were captured by linked data. Results: Baseline prevalence of sarcopenia according to FNIH (9.4%), EWGSOP (24.1%), AUS-POP F (12.0%), and AUS-POP E (10.7%) differed substantially. Sarcopenia did not increase the relative hazard ratio (HR) for falls-related hospitalization before or after adjustment for age (aHR): FNIH aHR 1.00 95%CI (0.69–1.47), EWGSOP aHR 1.20 95%CI (0.93–1.54), AUS-POP F aHR 0.96 95%CI (0.68–1.35), and AUS-POP E aHR 1.33 95%CI (0.94–1.88). When examining individual components of sarcopenia, only muscle strength and physical function but not ALM (adjusted for height 2 or BMI) were associated with falls-related hospitalization. Conclusion: Current definitions of sarcopenia were not associated with falls-related hospitalization risk in this cohort of community-dwelling older Australian women. Finally, measures of muscle strength and physical function, but not ALM (measured by DXA) may help discriminate the risk of falls-related hospitalization.

AB - Summary: Numerous sarcopenia definitions are not associated with increased falls-related hospitalization risk over 5 years to 9.5 years in older community-dwelling Australian women. Measures of muscle strength and physical function, but not appendicular lean mass (measured by dual-energy X-ray absorptiometry) may help discriminate the risk of falls-related hospitalization. Introduction: The aim of this prospective, population-based cohort study of 903 Caucasian-Australian women (mean age 79.9 ± 2.6 years) was to compare the clinical utility of four sarcopenia definitions for the prediction of falls-related hospitalization over 9.5 years. Methods: The four definitions were the United States Foundation for the National Institutes of Health (FNIH), the European Working Group on Sarcopenia in Older People (EWGSOP), and modified FNIH (AUS-POP F ) and EWGSOP (AUS-POP E ) definitions using Australian population-specific cut points (< 2 SD below the mean of young healthy Australian women). Components of sarcopenia including muscle strength, physical function, and appendicular lean mass (ALM) were quantified using hand grip strength, timed-up-and-go (TUG), and dual-energy X-ray absorptiometry (DXA), respectively. Incident 9.5-year falls-related hospitalization were captured by linked data. Results: Baseline prevalence of sarcopenia according to FNIH (9.4%), EWGSOP (24.1%), AUS-POP F (12.0%), and AUS-POP E (10.7%) differed substantially. Sarcopenia did not increase the relative hazard ratio (HR) for falls-related hospitalization before or after adjustment for age (aHR): FNIH aHR 1.00 95%CI (0.69–1.47), EWGSOP aHR 1.20 95%CI (0.93–1.54), AUS-POP F aHR 0.96 95%CI (0.68–1.35), and AUS-POP E aHR 1.33 95%CI (0.94–1.88). When examining individual components of sarcopenia, only muscle strength and physical function but not ALM (adjusted for height 2 or BMI) were associated with falls-related hospitalization. Conclusion: Current definitions of sarcopenia were not associated with falls-related hospitalization risk in this cohort of community-dwelling older Australian women. Finally, measures of muscle strength and physical function, but not ALM (measured by DXA) may help discriminate the risk of falls-related hospitalization.

KW - Falls-related hospitalization

KW - Geriatrics

KW - Muscle mass

KW - Muscle strength

KW - Physical function

UR - http://www.scopus.com/inward/record.url?scp=85056742688&partnerID=8YFLogxK

UR - http://purl.org/au-research/grants/NHMRC/254627

UR - http://purl.org/au-research/grants/NHMRC/303169

UR - http://purl.org/au-research/grants/NHMRC/572604

U2 - 10.1007/s00198-018-4755-7

DO - 10.1007/s00198-018-4755-7

M3 - Article

C2 - 30456572

AN - SCOPUS:85056742688

SN - 0937-941X

VL - 30

SP - 167

EP - 176

JO - Osteoporosis International

JF - Osteoporosis International

ER -

Utility of four sarcopenia criteria for the prediction of falls-related hospitalization in older Australian women

Abstract

Keywords

UN SDGs

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