Variable cytochrome P450 2D6 expression and metabolism of codeine and other opioid prodrugs: Implications for the Australian anaesthetist

R. A. Wilcox, H. Owen

    Research output: Contribution to journalReview article

    21 Citations (Scopus)

    Abstract

    Codeine is a popular opioid prodrug dependent on the activity of the specific cytochrome P450 enzyme 2D6 (CYP2D6). This enzyme catalyses the production of the potent analgesic metabolite morphine, but genetic studies have demonstrated that individuals from different ethnic groups exhibit considerable variability in the functional capacities of their expressed CYP2D6 enzymes, and pharmacological studies have shown many commonly prescribed drugs can reduce the action of CYP2D6 enzymes. These findings have significant clinical implications for the rational prescription of effective analgesia, especially in a multicultural country like Australia.

    Original languageEnglish
    Pages (from-to)611-619
    Number of pages9
    JournalAnaesthesia and Intensive Care
    Volume28
    Issue number6
    DOIs
    Publication statusPublished - Dec 2000

    Keywords

    • Analgesics
    • Codeine
    • Cytochrome P450 2D6
    • Ethylmorphine
    • Hydrocodone
    • Opioid
    • Oxycodone Enzymes
    • Tramadol

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