Variables of patient‐controlled analgesia 4: the relevance of bolus dose size to supplement a background infusion

H. Owen, M. T. Kluger, J. L. Plummer

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    22 Citations (Scopus)

    Abstract

    A range of self‐administered demand doses of morphine (0.4, 0.7 and 1.0 mg) were prescribed to supplement a fixed‐rate infusion (1.5 mg/hour) for pain control after gynaecological surgery. The number of demand doses administered during the first 25 hours after surgery was not significantly influenced by size of demand dose. There was a significant linear trend to increasing amount of demanded morphine with increasing bolus size. These results cast doubt on the usefulness of the concept of a minimum effective analgesic concentration of morphine.

    Original languageEnglish
    Pages (from-to)619-622
    Number of pages4
    JournalAnaesthesia
    Volume45
    Issue number8
    DOIs
    Publication statusPublished - Aug 1990

    Keywords

    • Analgesia; on‐demand, patient‐controlled
    • Pain; postoperative

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