Vascular endothelial growth factor receptor 1 (Flt1) and apoptosis in the preeclamptic placenta and effects of in vivo anti-hypertensive exposure

Rita Machaalani, Angela Makris, Charlene Thornton, Annemarie Hennessy

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objective: To test the hypothesis that vascular endothelial growth factor receptor 1 (Flt1) is negatively correlated with apoptosis in preeclampsia placentae, and to examine the effects of antihypertensive medication on apoptosis. Methods: Flt1 and TUNEL immunoreactivity were quantitatively compared in the stromal decidual cells, villous trophoblasts, and endothelial cells of placentae from uncomplicated pregnancies (NP, n = 34) to those in patients with preeclampsia (PE, n = 30), and those in patients with preeclampsia with superimposed intrauterine growth restriction (PE + IUGR, n = 7). Further analyses determined any correlations with the antepartum use of the antihypertensives clonidine and hydralazine. Results: There was no difference in either Flt1 or TUNEL when comparing PE placentae (with or without IUGR) with NP. There were no correlations with the use of the antihypertensives. Conclusion. Apoptotic levels do not correlate with Flt1 in preeclampsia placentae and are not regulated by invivo exposure to the antihypertensives clonidine and hydralazine.

Original languageEnglish
Pages (from-to)361-373
Number of pages13
JournalHYPERTENSION IN PREGNANCY
Volume27
Issue number4
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

Keywords

  • Apoptosis
  • Clonidine
  • IUGR
  • Preeclampsia
  • VEGF receptor 1

Fingerprint Dive into the research topics of 'Vascular endothelial growth factor receptor 1 (Flt1) and apoptosis in the preeclamptic placenta and effects of in vivo anti-hypertensive exposure'. Together they form a unique fingerprint.

Cite this