VASCULAR ENDOTHELIN RESPONSIVENESS AND RECEPTOR CHARACTERISTICS IN VITRO AND EFFECTS OF ENDOTHELIN RECEPTOR BLOCKADE IN VIVO IN CYCLOSPORIN HYPERTENSION

P. A. Phillips; K. A. Rolls; L. M. Burrell; D. Casley; K. L. Aldred; K. J. Hardy

doi:10.1111/j.1440-1681.1994.tb02501.x

VASCULAR ENDOTHELIN RESPONSIVENESS AND RECEPTOR CHARACTERISTICS IN VITRO AND EFFECTS OF ENDOTHELIN RECEPTOR BLOCKADE IN VIVO IN CYCLOSPORIN HYPERTENSION

P. A. Phillips, K. A. Rolls, L. M. Burrell, D. Casley, K. L. Aldred, K. J. Hardy

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

1. The aim of these studies was to determine the role of endothelin in cyclosporin A ([CsA], 10 mg/kg per day, s.c., for 30 days) hypertension in the rat. 2. There were no significant differences in plasma endothelin concentrations, in vitro mesenteric vascular membrane [¹²⁵I]‐endothelin‐l (ET‐1) binding characteristics or myographic vascular responses to endothelin‐1 between the CsA and control groups (systolic blood pressure 135 ± 1 vs 127 ± 1 mmHg, respectively, P<0.001). 3. Twenty‐four hours after selective endothelin type A receptor blockade in vivo with BQ123, blood pressure in CsA hypertensive rats was lowered to levels of normotensive controls. 4. These results suggest that changes in endothelin synthesis rather than changes in vascular sensitivity and/or ET‐1 receptor characteristics may contribute to CsA‐induced hypertension.

Original language	English
Pages (from-to)	223-226
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	21
Issue number	3
DOIs	https://doi.org/10.1111/j.1440-1681.1994.tb02501.x
Publication status	Published - Mar 1994
Externally published	Yes

Keywords

cyclosporin
endothelin
hypertension
vascular.

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Phillips, P. A., Rolls, K. A., Burrell, L. M., Casley, D., Aldred, K. L., & Hardy, K. J. (1994). VASCULAR ENDOTHELIN RESPONSIVENESS AND RECEPTOR CHARACTERISTICS IN VITRO AND EFFECTS OF ENDOTHELIN RECEPTOR BLOCKADE IN VIVO IN CYCLOSPORIN HYPERTENSION. Clinical and Experimental Pharmacology and Physiology, 21(3), 223-226. https://doi.org/10.1111/j.1440-1681.1994.tb02501.x

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abstract = "1. The aim of these studies was to determine the role of endothelin in cyclosporin A ([CsA], 10 mg/kg per day, s.c., for 30 days) hypertension in the rat. 2. There were no significant differences in plasma endothelin concentrations, in vitro mesenteric vascular membrane [125I]‐endothelin‐l (ET‐1) binding characteristics or myographic vascular responses to endothelin‐1 between the CsA and control groups (systolic blood pressure 135 ± 1 vs 127 ± 1 mmHg, respectively, P<0.001). 3. Twenty‐four hours after selective endothelin type A receptor blockade in vivo with BQ123, blood pressure in CsA hypertensive rats was lowered to levels of normotensive controls. 4. These results suggest that changes in endothelin synthesis rather than changes in vascular sensitivity and/or ET‐1 receptor characteristics may contribute to CsA‐induced hypertension.",

keywords = "cyclosporin, endothelin, hypertension, vascular.",

author = "Phillips, {P. A.} and Rolls, {K. A.} and Burrell, {L. M.} and D. Casley and Aldred, {K. L.} and Hardy, {K. J.}",

year = "1994",

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VASCULAR ENDOTHELIN RESPONSIVENESS AND RECEPTOR CHARACTERISTICS IN VITRO AND EFFECTS OF ENDOTHELIN RECEPTOR BLOCKADE IN VIVO IN CYCLOSPORIN HYPERTENSION. / Phillips, P. A.; Rolls, K. A.; Burrell, L. M.; Casley, D.; Aldred, K. L.; Hardy, K. J.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 21, No. 3, 03.1994, p. 223-226.

Research output: Contribution to journal › Article › peer-review

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AB - 1. The aim of these studies was to determine the role of endothelin in cyclosporin A ([CsA], 10 mg/kg per day, s.c., for 30 days) hypertension in the rat. 2. There were no significant differences in plasma endothelin concentrations, in vitro mesenteric vascular membrane [125I]‐endothelin‐l (ET‐1) binding characteristics or myographic vascular responses to endothelin‐1 between the CsA and control groups (systolic blood pressure 135 ± 1 vs 127 ± 1 mmHg, respectively, P<0.001). 3. Twenty‐four hours after selective endothelin type A receptor blockade in vivo with BQ123, blood pressure in CsA hypertensive rats was lowered to levels of normotensive controls. 4. These results suggest that changes in endothelin synthesis rather than changes in vascular sensitivity and/or ET‐1 receptor characteristics may contribute to CsA‐induced hypertension.

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