Vasoconstriction induced by inhalation of irritant vapour is associated with appearance of Fos protein in C1 catecholamine neurons in rabbit medulla oblongata

Z. J. Gieroba, Ying Hui Yu, W. W. Blessing

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    The medulla oblongata was examined with Fos and tyrosine hydroxylase (TH) immunohistochemistry after 2 h of intermittent nasopharyngeal stimulation with formaldehyde vapour in the conscious rabbit. The stimulation caused apnoea, bradycardia and a rise in blood pressure known to be associated with vigorous vasocontriction. Fos-positive neurons occurred in the spinal trigeminal nucleus, the nucleus tractus solitarius, the raphe nuclei and the ventrolateral medulla. In the rostral ventolateral medulla, 68% of the Fos-positive neurons were TH-positive C1 cells. Our data indicate that nasopharyngeally-evoked peripheral vasoconstriction is associated with activation of C1 neurons.

    Original languageEnglish
    Pages (from-to)157-161
    Number of pages5
    JournalBrain Research
    Volume636
    Issue number1
    DOIs
    Publication statusPublished - 4 Feb 1994

    Keywords

    • Arterial pressure
    • c-fos
    • Nasopharyngeal reflex
    • Rostral ventrolateral medulla
    • Spinal trigeminal nucleus
    • Tyrosine hydroxylase

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