TY - JOUR
T1 - Vasopressin secretion after stimulation of abdominal vagus in rabbit
T2 - Role of A1 norepinephrine neurons
AU - Gieroba, Z. J.
AU - Blessing, W. W.
PY - 1994/6
Y1 - 1994/6
N2 - We determined whether electrical stimulation of the abdominal vagus nerve causes secretion of vasopressin in the rabbit and whether inhibition of neuronal function in the A1 region of the medulla oblongata impairs this secretion. In urethan-anesthetized rabbits, electrical stimulation of the abdominal vagus (5-min train of cathodal pulses, 0.5 ms duration, 20 Hz, 0.5- 1 mA) increased plasma vasopressin from 37 ± 8 to 133 ± 19 pg/ml (P < 0.01, n = 11). Prior section of the cervical vagus completely prevented the increase seen with stimulation of the abdominal vagus. Injecting the inhibitory agent muscimol (1 nmol) 2 mm dorsal to the A1 area did not significantly reduce the vasopressin response to abdominal vagal stimulation. However, when muscimol was injected into the A1 area, the vagally mediated increase in plasma vasopressin was completely prevented. Our results show that stimulation of abdominal vagal afferents causes secretion of vasopressin in the rabbit via a central pathway that includes neurons in the A1 area.
AB - We determined whether electrical stimulation of the abdominal vagus nerve causes secretion of vasopressin in the rabbit and whether inhibition of neuronal function in the A1 region of the medulla oblongata impairs this secretion. In urethan-anesthetized rabbits, electrical stimulation of the abdominal vagus (5-min train of cathodal pulses, 0.5 ms duration, 20 Hz, 0.5- 1 mA) increased plasma vasopressin from 37 ± 8 to 133 ± 19 pg/ml (P < 0.01, n = 11). Prior section of the cervical vagus completely prevented the increase seen with stimulation of the abdominal vagus. Injecting the inhibitory agent muscimol (1 nmol) 2 mm dorsal to the A1 area did not significantly reduce the vasopressin response to abdominal vagal stimulation. However, when muscimol was injected into the A1 area, the vagally mediated increase in plasma vasopressin was completely prevented. Our results show that stimulation of abdominal vagal afferents causes secretion of vasopressin in the rabbit via a central pathway that includes neurons in the A1 area.
KW - A catecholamine neurons
KW - arterial pressure
KW - caudal ventrolateral medulla
KW - muscimol
KW - vasopressin
UR - http://www.scopus.com/inward/record.url?scp=0028118127&partnerID=8YFLogxK
U2 - 10.1152/ajpregu.1994.266.6.r1885
DO - 10.1152/ajpregu.1994.266.6.r1885
M3 - Article
C2 - 8024043
AN - SCOPUS:0028118127
SN - 0363-6119
VL - 266
SP - R1885-R1890
JO - American Journal of Physiology: Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology: Regulatory Integrative and Comparative Physiology
IS - 6
ER -