Vasopressin synergistically stimulates DNA synthesis in normal and regenerating rat liver cell cultures in the presence of hepatocyte growth factor

A. M.J. Metcalfe, P. Phillips, R. M. Dixon, G. K. Radda

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Liver regeneration is significantly impaired in rats with both α-adrenergic hepatic denervation and hereditary vasopressin deficiency. This may implicate a direct role for these agonists in the process of compensatory hyperplasia. The mitogenic capacities of norepinephrine, vasopressin and hepatocyte growth factor (HGF), either alone or in combination were investigated by [3H]thymidine incorporation into hepatocyte cultures prepared from normal and regenerating rat livers. The results show that normal hepatocytes incorporate less [3H]thymidine in response to HGF than do regenerating hepatocytes. In addition, physiological concentrations of vasopressin cause a synergistic stimulation of [3H]thymidine uptake in rat liver cells in the presence of HGF.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalJournal of Molecular Endocrinology
Volume18
Issue number2
DOIs
Publication statusPublished - 1997
Externally publishedYes

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