Ventilatory responses to sustained eucapnic hypoxia in healthy males during wakefulness and NREM sleep

R. Douglas McEvoy, Rainer M. Popovic, Nicholas A. Saunders, David P. White

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    The effects of sustained eucapnic hypoxia (SEH, 20 minutes SaO2, ~80%) on ventilation and supraglottic airflow resistance (Rua) plus genioglossal (gg) and diaphragmatic (di) electromyograms (EMGs) were compared during wakefulness and nonrapid eye movement (NREM) sleep in six healthy normal male subjects. Early augmentation of ventilation was followed by decline or roll- off in both states. The augmentation of ventilation was less in sleep than wakefulness (e.g., after 5 minutes hypoxia, 140% and 167% of baseline, respectively, p < 0.05). This appeared to be due to three factors: 1) sleep- related increases in Rua [the ventilatory responses to SEH (sleep vs. awake) were inversely related to changes in Rua (sleep vs. awake) (p < 0.05)], 2. reduced central neural drive (inspiratory phasic EMG di after 5 minutes SEH, 111% and 121% of baseline, p < 0.05), and 3) failure to increase respiratory frequency during SEH sleep. There was also a nonsignificant trend to a biphasic response in EMG gg and a small increase in Rua during SEH.

    Original languageEnglish
    Pages (from-to)1008-1011
    Number of pages4
    JournalSLEEP
    Volume20
    Issue number11
    DOIs
    Publication statusPublished - 1 Jan 1997

    Keywords

    • Diaphragmatic electromyogram
    • Genioglossal electromyogram
    • NREM sleep
    • Sustained eucapnic hypoxia
    • Upper airways resistance
    • Ventilation
    • Wakefulness

    Fingerprint Dive into the research topics of 'Ventilatory responses to sustained eucapnic hypoxia in healthy males during wakefulness and NREM sleep'. Together they form a unique fingerprint.

    Cite this