Video image analysis of AgNOR distribution in the normal and adenomatous colorectum

Sandy C. Weeks; Dimitra Beroukas; Lynn R. Jarvis; Richard Whitehead

doi:10.1002/path.1711660209

Video image analysis of AgNOR distribution in the normal and adenomatous colorectum

Sandy C. Weeks, Dimitra Beroukas, Lynn R. Jarvis, Richard Whitehead

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The nucleolar organizer regions (AgNORs) have been studied by video image analysis in the normal colorectum and in adenomas arising there. Total AgNOR area was measured in conjunction with the total area of nuclei and expressed as a ratio. AgNORs are found to predominate in the proliferative regions of the normal mucosal crypt, and the ratio of AgNOR to nuclear area proved significantly greater in the normal colon than in the rectum and far greater in colorectal adenomas. Further, there is a significant difference between the ration in tubular as opposed to villous patterns of adenomatous growth in the colon but not in the rectum. When classified according to their degree of dysplasia, adenomas in the rectum exhibit a significantly higher ratio of AgNOR to nuclear area as the degree of dysplasia increases in severity. This correlation is not shown in the colon.

Original language	English
Pages (from-to)	139-145
Number of pages	7
Journal	Journal of Pathology
Volume	166
Issue number	2
DOIs	https://doi.org/10.1002/path.1711660209
Publication status	Published - Feb 1992

Keywords

Morphometry
proliferative
ratio

Access to Document

10.1002/path.1711660209Licence: In Copyright

Cite this

@article{3d0a0e7830a346e4b008e518cd1575b8,

title = "Video image analysis of AgNOR distribution in the normal and adenomatous colorectum",

abstract = "The nucleolar organizer regions (AgNORs) have been studied by video image analysis in the normal colorectum and in adenomas arising there. Total AgNOR area was measured in conjunction with the total area of nuclei and expressed as a ratio. AgNORs are found to predominate in the proliferative regions of the normal mucosal crypt, and the ratio of AgNOR to nuclear area proved significantly greater in the normal colon than in the rectum and far greater in colorectal adenomas. Further, there is a significant difference between the ration in tubular as opposed to villous patterns of adenomatous growth in the colon but not in the rectum. When classified according to their degree of dysplasia, adenomas in the rectum exhibit a significantly higher ratio of AgNOR to nuclear area as the degree of dysplasia increases in severity. This correlation is not shown in the colon.",

keywords = "Morphometry, proliferative, ratio",

author = "Weeks, {Sandy C.} and Dimitra Beroukas and Jarvis, {Lynn R.} and Richard Whitehead",

year = "1992",

month = feb,

doi = "10.1002/path.1711660209",

language = "English",

volume = "166",

pages = "139--145",

journal = "Journal of Pathology",

issn = "0022-3417",

publisher = "John Wiley & Sons Ltd",

number = "2",

}

TY - JOUR

T1 - Video image analysis of AgNOR distribution in the normal and adenomatous colorectum

AU - Weeks, Sandy C.

AU - Beroukas, Dimitra

AU - Jarvis, Lynn R.

AU - Whitehead, Richard

PY - 1992/2

Y1 - 1992/2

N2 - The nucleolar organizer regions (AgNORs) have been studied by video image analysis in the normal colorectum and in adenomas arising there. Total AgNOR area was measured in conjunction with the total area of nuclei and expressed as a ratio. AgNORs are found to predominate in the proliferative regions of the normal mucosal crypt, and the ratio of AgNOR to nuclear area proved significantly greater in the normal colon than in the rectum and far greater in colorectal adenomas. Further, there is a significant difference between the ration in tubular as opposed to villous patterns of adenomatous growth in the colon but not in the rectum. When classified according to their degree of dysplasia, adenomas in the rectum exhibit a significantly higher ratio of AgNOR to nuclear area as the degree of dysplasia increases in severity. This correlation is not shown in the colon.

AB - The nucleolar organizer regions (AgNORs) have been studied by video image analysis in the normal colorectum and in adenomas arising there. Total AgNOR area was measured in conjunction with the total area of nuclei and expressed as a ratio. AgNORs are found to predominate in the proliferative regions of the normal mucosal crypt, and the ratio of AgNOR to nuclear area proved significantly greater in the normal colon than in the rectum and far greater in colorectal adenomas. Further, there is a significant difference between the ration in tubular as opposed to villous patterns of adenomatous growth in the colon but not in the rectum. When classified according to their degree of dysplasia, adenomas in the rectum exhibit a significantly higher ratio of AgNOR to nuclear area as the degree of dysplasia increases in severity. This correlation is not shown in the colon.

KW - Morphometry

KW - proliferative

KW - ratio

UR - http://www.scopus.com/inward/record.url?scp=0026587209&partnerID=8YFLogxK

U2 - 10.1002/path.1711660209

DO - 10.1002/path.1711660209

M3 - Article

C2 - 1560314

AN - SCOPUS:0026587209

SN - 0022-3417

VL - 166

SP - 139

EP - 145

JO - Journal of Pathology

JF - Journal of Pathology

IS - 2

ER -

Video image analysis of AgNOR distribution in the normal and adenomatous colorectum

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this