Viral diversity and dynamics in an infant gut

Mya Breitbart, Matthew Haynes, Scott Kelley, Florent Angly, Robert A. Edwards, Ben Felts, Joseph M. Mahaffy, Jennifer Mueller, James Nulton, Steve Rayhawk, Beltran Rodriguez-Brito, Peter Salamon, Forest Rohwer

Research output: Contribution to journalArticlepeer-review

188 Citations (Scopus)

Abstract

Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.

Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalResearch in Microbiology
Volume159
Issue number5
DOIs
Publication statusPublished - Jun 2008
Externally publishedYes

Keywords

  • Feces
  • Gut
  • Infant
  • Metagenomics
  • Microarray
  • Phage
  • Virus

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