Viral diversity and dynamics in an infant gut

Mya Breitbart; Matthew Haynes; Scott Kelley; Florent Angly; Robert A. Edwards; Ben Felts; Joseph M. Mahaffy; Jennifer Mueller; James Nulton; Steve Rayhawk; Beltran Rodriguez-Brito; Peter Salamon; Forest Rohwer

doi:10.1016/j.resmic.2008.04.006

Viral diversity and dynamics in an infant gut

Mya Breitbart, Matthew Haynes, Scott Kelley, Florent Angly, Robert A. Edwards, Ben Felts, Joseph M. Mahaffy, Jennifer Mueller, James Nulton, Steve Rayhawk, Beltran Rodriguez-Brito, Peter Salamon, Forest Rohwer

Research output: Contribution to journal › Article › peer-review

273 Citations (Scopus)

Abstract

Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.

Original language	English
Pages (from-to)	367-373
Number of pages	7
Journal	Research in Microbiology
Volume	159
Issue number	5
DOIs	https://doi.org/10.1016/j.resmic.2008.04.006
Publication status	Published - Jun 2008
Externally published	Yes

Keywords

Feces
Gut
Infant
Metagenomics
Microarray
Phage
Virus

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10.1016/j.resmic.2008.04.006Licence: In Copyright

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abstract = "Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.",

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AU - Breitbart, Mya

AU - Haynes, Matthew

AU - Kelley, Scott

AU - Angly, Florent

AU - Edwards, Robert A.

AU - Felts, Ben

AU - Mahaffy, Joseph M.

AU - Mueller, Jennifer

AU - Nulton, James

AU - Rayhawk, Steve

AU - Rodriguez-Brito, Beltran

AU - Salamon, Peter

AU - Rohwer, Forest

PY - 2008/6

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AB - Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.

KW - Feces

KW - Gut

KW - Infant

KW - Metagenomics

KW - Microarray

KW - Phage

KW - Virus

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JO - Research in Microbiology

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Viral diversity and dynamics in an infant gut

Abstract

Keywords

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