Vortex Fluidic Mediated Synthesis of Macroporous Bovine Serum Albumin-Based Microspheres

Xuan Luo, Ahmed Hussein Mohammed Al-Antaki, David P Harvey, Yinlan Ruan, Shan He, Wei Zhang, Colin L Raston

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Macroporous bovine serum albumin (BSA) nanoparticles with controllable diameter were readily fabricated in a rapidly rotating angled glass tube in a vortex fluidic device (VFD). Systematically varying the rotational speed and the ratio of BSA, ethanol, and glutaraldehyde led to conditions for generating ca. 600 nm diameter macroporous particles that have intrinsic fluorescence emission at 520 nm when excited at 490 nm. The presence of the macropores increased the absorption efficiency of rhodamine B with potential applications for drug delivery purpose, compared with BSA nanoparticles having surfaces devoid of pores. Further control over the size of BSA nanoparticles occurred in the presence of C-phycocyanin protein during the VFD processing, along with control of their shape, from spheres to pockets, as established in exploring the parameter space of the microfluidic device.
Original languageEnglish
Pages (from-to)27224-27232
Number of pages9
JournalACS Applied Materials & Interfaces
Issue number32
Early online date20 Jul 2018
Publication statusPublished - 15 Aug 2018


  • bovine serum albumin
  • macroporous
  • Nanoparticle
  • fluorescence
  • microfluidics
  • nanoparticle


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