Warfarin and Warfarin‐Alcohol Levels in Anticoagulated Patients

P. Duffield; A. M. Duffield; M Kennedy; D. J. Birkett; D. N. Wade

doi:10.1111/j.1445-5994.1979.tb03390.x

Warfarin and Warfarin‐Alcohol Levels in Anticoagulated Patients

P. Duffield, A. M. Duffield, M Kennedy, D. J. Birkett, D. N. Wade

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Summary: The relationship between dosage, prothrombin ratio, and steady‐state plasma concentrations of warfarin and warfarin‐alcohol, were determined in 43 patients regularly attending an anticoagulant clinic. The warfarin and warfarin‐alcohol concentrations were determined by a gas chromatographic mass spectroscopic (GC/MS) method. A significant correlation was found between the dose and the plasma level of warfarin. There was no significant correlation between the prothrombin ratio and the dose of warfarin, the steady‐state plasma levels of warfarin or warfarin‐alcohol, or the sum of their plasma concentrations. Measurement of the plasma levels of warfarin and warfarin‐alcohol is likely to be of little help clinically other than to detect failure of compliance or malabsorption.

Original language	English
Pages (from-to)	534-537
Number of pages	4
Journal	Australian and New Zealand Journal of Medicine
Volume	9
Issue number	5
DOIs	https://doi.org/10.1111/j.1445-5994.1979.tb03390.x
Publication status	Published - Oct 1979
Externally published	Yes

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title = "Warfarin and Warfarin‐Alcohol Levels in Anticoagulated Patients",

abstract = "Summary: The relationship between dosage, prothrombin ratio, and steady‐state plasma concentrations of warfarin and warfarin‐alcohol, were determined in 43 patients regularly attending an anticoagulant clinic. The warfarin and warfarin‐alcohol concentrations were determined by a gas chromatographic mass spectroscopic (GC/MS) method. A significant correlation was found between the dose and the plasma level of warfarin. There was no significant correlation between the prothrombin ratio and the dose of warfarin, the steady‐state plasma levels of warfarin or warfarin‐alcohol, or the sum of their plasma concentrations. Measurement of the plasma levels of warfarin and warfarin‐alcohol is likely to be of little help clinically other than to detect failure of compliance or malabsorption.",

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AU - Kennedy, M

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AU - Wade, D. N.

PY - 1979/10

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N2 - Summary: The relationship between dosage, prothrombin ratio, and steady‐state plasma concentrations of warfarin and warfarin‐alcohol, were determined in 43 patients regularly attending an anticoagulant clinic. The warfarin and warfarin‐alcohol concentrations were determined by a gas chromatographic mass spectroscopic (GC/MS) method. A significant correlation was found between the dose and the plasma level of warfarin. There was no significant correlation between the prothrombin ratio and the dose of warfarin, the steady‐state plasma levels of warfarin or warfarin‐alcohol, or the sum of their plasma concentrations. Measurement of the plasma levels of warfarin and warfarin‐alcohol is likely to be of little help clinically other than to detect failure of compliance or malabsorption.

AB - Summary: The relationship between dosage, prothrombin ratio, and steady‐state plasma concentrations of warfarin and warfarin‐alcohol, were determined in 43 patients regularly attending an anticoagulant clinic. The warfarin and warfarin‐alcohol concentrations were determined by a gas chromatographic mass spectroscopic (GC/MS) method. A significant correlation was found between the dose and the plasma level of warfarin. There was no significant correlation between the prothrombin ratio and the dose of warfarin, the steady‐state plasma levels of warfarin or warfarin‐alcohol, or the sum of their plasma concentrations. Measurement of the plasma levels of warfarin and warfarin‐alcohol is likely to be of little help clinically other than to detect failure of compliance or malabsorption.

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Warfarin and Warfarin‐Alcohol Levels in Anticoagulated Patients

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