Warfarin and Warfarin‐Alcohol Levels in Anticoagulated Patients

P. Duffield, A. M. Duffield, M Kennedy, D. J. Birkett, D. N. Wade

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Summary: The relationship between dosage, prothrombin ratio, and steady‐state plasma concentrations of warfarin and warfarin‐alcohol, were determined in 43 patients regularly attending an anticoagulant clinic. The warfarin and warfarin‐alcohol concentrations were determined by a gas chromatographic mass spectroscopic (GC/MS) method. A significant correlation was found between the dose and the plasma level of warfarin. There was no significant correlation between the prothrombin ratio and the dose of warfarin, the steady‐state plasma levels of warfarin or warfarin‐alcohol, or the sum of their plasma concentrations. Measurement of the plasma levels of warfarin and warfarin‐alcohol is likely to be of little help clinically other than to detect failure of compliance or malabsorption.

Original languageEnglish
Pages (from-to)534-537
Number of pages4
JournalAustralian and New Zealand Journal of Medicine
Volume9
Issue number5
DOIs
Publication statusPublished - Oct 1979
Externally publishedYes

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