Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome

Lisa Moran; Manila Noakes; Gary Wittert; Peter Clifton; Robert Norman

doi:10.1016/j.rbmo.2012.07.013

Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome

Lisa Moran, Manila Noakes, Gary Wittert, Peter Clifton, Robert Norman

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n = 14) and without (n = 13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P = 0.026) and sICAM-1 (P = 0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss.

Original language	English
Pages (from-to)	500-503
Number of pages	4
Journal	Reproductive Biomedicine Online
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.rbmo.2012.07.013
Publication status	Published - Nov 2012

Keywords

cardiovascular disease
inflammation
polycystic ovary syndrome
weight loss

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.rbmo.2012.07.013

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title = "Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome",

abstract = "Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n = 14) and without (n = 13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P = 0.026) and sICAM-1 (P = 0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss.",

keywords = "cardiovascular disease, inflammation, polycystic ovary syndrome, weight loss",

author = "Lisa Moran and Manila Noakes and Gary Wittert and Peter Clifton and Robert Norman",

year = "2012",

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doi = "10.1016/j.rbmo.2012.07.013",

language = "English",

volume = "25",

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journal = "Reproductive Biomedicine Online",

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T1 - Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome

AU - Moran, Lisa

AU - Noakes, Manila

AU - Wittert, Gary

AU - Clifton, Peter

AU - Norman, Robert

PY - 2012/11

Y1 - 2012/11

N2 - Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n = 14) and without (n = 13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P = 0.026) and sICAM-1 (P = 0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss.

AB - Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n = 14) and without (n = 13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P = 0.026) and sICAM-1 (P = 0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss.

KW - cardiovascular disease

KW - inflammation

KW - polycystic ovary syndrome

KW - weight loss

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U2 - 10.1016/j.rbmo.2012.07.013

DO - 10.1016/j.rbmo.2012.07.013

M3 - Article

SN - 1472-6483

VL - 25

SP - 500

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JO - Reproductive Biomedicine Online

JF - Reproductive Biomedicine Online

IS - 5

ER -

Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome

Abstract

Keywords

UN SDGs

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