TY - JOUR
T1 - Western australian pregnancy cohort (raine) study
T2 - Generation 1
AU - Dontje, Manon L.
AU - Eastwood, Peter
AU - Straker, Leon
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Purpose The purpose of the Raine Study is to improve human health and well-being by studying the life-course of a cohort of Western Australians, based on a life-course conceptual framework that considers interactions between genetics, phenotypes, behaviours, the environment and developmental and social outcomes. Participants Between May 1989 and November 1991, 2900 pregnant women were enrolled in the Raine Study in Perth, Western Australia. In total, 2730 women gave birth to 2868 children (Generation 2) between August 1989 and April 1992. The mothers and fathers of Generation 2 are referred to as Generation 1 of the Raine Study. In the most recent Generation 1 follow-up, 636 mothers and 462 fathers participated. Findings to date Until the 26-year follow-up of Generation 1 the focus of research within the Raine Study was on outcomes in Generation 2, with information on the parents mainly being used to examine its influence on their children's outcomes. For example, recent findings showed that several characteristics of mothers, such as obesity, early mid-gestational weight gain and socioeconomic status were associated with non-Alcoholic fatty liver disease, adiposity and cardiometabolic characteristics in offspring. Other findings showed that parents with back pain were more likely to have offspring who experienced back pain. Also, non-linear and dynamic relationships were found between maternal working hours and offspring overweight or obesity. Future plans The Raine Study will continue to provide access to its dense longitudinal genetic, phenotypic, behavioural, environmental, developmental and social data to undertake studies with the ultimate goal of improving human health and well-being. Analyses of data from the recent Generation 1 year 26 follow-up are underway. Trial registration number ACTRN12617001599369
AB - Purpose The purpose of the Raine Study is to improve human health and well-being by studying the life-course of a cohort of Western Australians, based on a life-course conceptual framework that considers interactions between genetics, phenotypes, behaviours, the environment and developmental and social outcomes. Participants Between May 1989 and November 1991, 2900 pregnant women were enrolled in the Raine Study in Perth, Western Australia. In total, 2730 women gave birth to 2868 children (Generation 2) between August 1989 and April 1992. The mothers and fathers of Generation 2 are referred to as Generation 1 of the Raine Study. In the most recent Generation 1 follow-up, 636 mothers and 462 fathers participated. Findings to date Until the 26-year follow-up of Generation 1 the focus of research within the Raine Study was on outcomes in Generation 2, with information on the parents mainly being used to examine its influence on their children's outcomes. For example, recent findings showed that several characteristics of mothers, such as obesity, early mid-gestational weight gain and socioeconomic status were associated with non-Alcoholic fatty liver disease, adiposity and cardiometabolic characteristics in offspring. Other findings showed that parents with back pain were more likely to have offspring who experienced back pain. Also, non-linear and dynamic relationships were found between maternal working hours and offspring overweight or obesity. Future plans The Raine Study will continue to provide access to its dense longitudinal genetic, phenotypic, behavioural, environmental, developmental and social data to undertake studies with the ultimate goal of improving human health and well-being. Analyses of data from the recent Generation 1 year 26 follow-up are underway. Trial registration number ACTRN12617001599369
KW - health
KW - life-course
KW - longitudinal
KW - multi-generational
KW - observational
KW - pregnancy
KW - Raine Study
UR - http://www.scopus.com/inward/record.url?scp=85066604435&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/880441
UR - http://purl.org/au-research/grants/NHMRC/930745
UR - http://purl.org/au-research/grants/NHMRC/963209
UR - http://purl.org/au-research/grants/NHMRC/211912
UR - http://purl.org/au-research/grants/NHMRC/003209
UR - http://purl.org/au-research/grants/NHMRC/32300
UR - http://purl.org/au-research/grants/NHMRC/403981
UR - http://purl.org/au-research/grants/NHMRC/353514
UR - http://purl.org/au-research/grants/NHMRC/458623
UR - http://purl.org/au-research/grants/NHMRC/403968
UR - http://purl.org/au-research/grants/NHMRC/572613
UR - http://purl.org/au-research/grants/NHMRC/1084947
UR - http://purl.org/au-research/grants/NHMRC/1080492
U2 - 10.1136/bmjopen-2018-026276
DO - 10.1136/bmjopen-2018-026276
M3 - Article
C2 - 31138581
AN - SCOPUS:85066604435
VL - 9
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 5
M1 - e026276
ER -