What are the compared rates of regression of Barrett’s oesophagus observed after surgical or prolonged maintenance therapy?

M France, R Ackroyd, David I Watson

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

It is generally accepted that Barrett's esophagus (or columnar lined esophagus) develops as a response to the reflux of both gastric and duodenal contents into the lumen of the distal esophagus, with consequent exposure of the esophageal mucosa to deleterious effects of these substances. It would therefore seem reasonable to hypothesise that eliminating exposure of this mucosa to gastric and duodenal fluids, either by medical or surgical intervention, might be followed by regression of Barrett's esophagus. A knowledge of whether this in fact happens is very important, as Barrett's esophagus is a premalignant condition, which can progress to adenocarcinoma of the esophagus. Furthermore, the incidence of this cancer has risen dramatically over the last three decades. Fortunately, a number of studies have been published which do address the issue of whether either maintenance medical therapy or antireflux surgery is followed by regression of Barrett's esophagus, and these enable the question to be answered with some certainty.
Original languageEnglish
Title of host publicationBarrett's esophagus
EditorsRobert Giuli, Jorg Rudiger Siewert, Daniel Courtier, Carmelo Scarpignato
Place of PublicationFrance
PublisherOESO
Publication statusPublished - Sep 2000
Externally publishedYes
Event6th OESO World Congress: Barrett 2000 – Transition to Telemedicine - Paris, France
Duration: 1 Sep 20006 Sep 2000
Conference number: 6th

Conference

Conference6th OESO World Congress
Abbreviated title6th OESO
Country/TerritoryFrance
CityParis
Period1/09/006/09/00

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