What can we learn from the microbial ecological interactions associated with polymicrobial diseases?

John Antiabong, Andrew Ball, Wayne Boardman

    Research output: Contribution to journalArticle

    Abstract

    Periodontal diseases in humans and animals are model polymicrobial diseases which are associated with a shift in the microbial community structure and function; there is therefore a need to investigate these diseases from a microbial ecological perspective. This review highlights three important areas of microbial ecological investigation of polymicrobial diseases and the lessons that could be learnt: (1) identification of disease-associated microbes and the implications for choice of anti-infective treatment; (2) the implications associated with vaccine design and development and (3) application of the dynamics of microbial interaction in the discovery of novel anti-infective agents. This review emphasises the need to invigorate microbial ecological approaches to the study of periodontal diseases and other polymicrobial diseases for greater understanding of the ecological interactions between and within the biotic and abiotic factors of the environment.

    Original languageEnglish
    Pages (from-to)30-36
    Number of pages7
    JournalVETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
    Volume158
    Issue number1-2
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Anti-infective
    • Microbial ecology
    • Molecular tools
    • Periodontal disease
    • Polymicrobial disease
    • Vaccine

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