What Does it Take to Make Model-Informed Precision Dosing Common Practice? Report from the 1st Asian Symposium on Precision Dosing

Thomas M. Polasek, Amin Rostami-Hodjegan, Dong Seok Yim, Masoud Jamei, Howard Lee, Holly Kimko, Jae Kyoung Kim, Phuong Thi Thu Nguyen, Adam S. Darwich, Jae Gook Shin

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7 Citations (Scopus)

Abstract

Model-informed precision dosing (MIPD) is modeling and simulation in healthcare to predict the drug dose for a given patient based on their individual characteristics that is most likely to improve efficacy and/or lower toxicity in comparison to traditional dosing. This paper describes the background and status of MIPD and the activities at the 1st Asian Symposium of Precision Dosing. The theme of the meeting was the question, “What does it take to make MIPD common practice?” Formal presentations highlighted the distinction between genetic and non-genetic sources of variability in drug exposure and response, the use of modeling and simulation as decision support tools, and the facilitators to MIPD implementation. A panel discussion addressed the types of models used for MIPD, how the pharmaceutical industry views MIPD, ways to upscale MIPD beyond academic hospital centers, and the essential role of healthcare professional education as a way to progress. The meeting concluded with an ongoing commitment to use MIPD to improve patient care.

Original languageEnglish
Article number17
Number of pages9
JournalAAPS Journal
Volume21
Issue number2
DOIs
Publication statusPublished - Mar 2019
Externally publishedYes

Keywords

  • MIPD
  • modeling and simulation

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    Polasek, T. M., Rostami-Hodjegan, A., Yim, D. S., Jamei, M., Lee, H., Kimko, H., Kim, J. K., Nguyen, P. T. T., Darwich, A. S., & Shin, J. G. (2019). What Does it Take to Make Model-Informed Precision Dosing Common Practice? Report from the 1st Asian Symposium on Precision Dosing. AAPS Journal, 21(2), [17]. https://doi.org/10.1208/s12248-018-0286-6