TY - JOUR
T1 - What is a Clinically Meaningful Target for Positive Airway Pressure Adherence?
AU - Oh, Aaron
AU - Grivell, Nicole
AU - Chai-Coetzer, Ching Li
PY - 2021/3
Y1 - 2021/3
N2 - Although good adherence to continuous positive airway pressure (PAP) traditionally is defined as greater than or equal to 4 hours/night, the origins and rationale for this remain unclear. Research studies report variation in optimal duration of PAP adherence, depending on outcome of interest. Evidence demonstrates benefit with PAP for daytime sleepiness, quality of life, neurocognitive outcomes, depression, and hypertension, predominantly in symptomatic, moderate–severe obstructive sleep apnea. Recent randomized controlled trials, however, have failed to demonstrate a reduction in cardiovascular and mortality risks. This review explores the question of what can be considered a clinically meaningful outcome for PAP adherence.
AB - Although good adherence to continuous positive airway pressure (PAP) traditionally is defined as greater than or equal to 4 hours/night, the origins and rationale for this remain unclear. Research studies report variation in optimal duration of PAP adherence, depending on outcome of interest. Evidence demonstrates benefit with PAP for daytime sleepiness, quality of life, neurocognitive outcomes, depression, and hypertension, predominantly in symptomatic, moderate–severe obstructive sleep apnea. Recent randomized controlled trials, however, have failed to demonstrate a reduction in cardiovascular and mortality risks. This review explores the question of what can be considered a clinically meaningful outcome for PAP adherence.
KW - Adherence
KW - Compliance
KW - Obstructive sleep apnea
KW - PAP
KW - Positive airway pressure
UR - http://www.scopus.com/inward/record.url?scp=85097111610&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1134954
U2 - 10.1016/j.jsmc.2020.10.001
DO - 10.1016/j.jsmc.2020.10.001
M3 - Review article
C2 - 33485522
AN - SCOPUS:85097111610
SN - 1556-407X
VL - 16
SP - 1
EP - 10
JO - Sleep Medicine Clinics
JF - Sleep Medicine Clinics
IS - 1
ER -