Abstract
Despite short-term successes and a marked reduction in the overall incidence of acute rejection, long-term allograft survival after kidney transplantation has remained largely unchanged for the past three decades.1 Less than 50% of our transplant recipients have survived with a functioning graft 15 years after transplantation. The most important outcome of transplantation from the patient’s perspective is the survival of their graft.2 Strategies to improve longer-term graft outcomes remain a key priority for patients, caregivers, and health professionals. Balancing the allograft response and reducing toxicity associated with immunosuppression is essential to achieving optimal outcomes. Current immunosuppression usually includes a combination of induction therapies, such as T cell–depleting agents or IL-2 receptor antibodies, followed by a typical maintenance regimen of calcineurin inhibitors, antiproliferative agents, and corticosteroids.
Original language | English |
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Pages (from-to) | 6-8 |
Number of pages | 3 |
Journal | Journal of The American Society of Nephrology |
Volume | 31 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2020 |
Keywords
- Steroids
- Kidney transplantation
- Acute allograft rejection
- Delayed graft function