When less becomes more: Life and losses without the ‘roids’?

Germaine Wong, Wai Hon Lim, Jonathan C. Craig

Research output: Contribution to journalEditorial

1 Citation (Scopus)


Despite short-term successes and a marked reduction in the overall incidence of acute rejection, long-term allograft survival after kidney transplantation has remained largely unchanged for the past three decades.1 Less than 50% of our transplant recipients have survived with a functioning graft 15 years after transplantation. The most important outcome of transplantation from the patient’s perspective is the survival of their graft.2 Strategies to improve longer-term graft outcomes remain a key priority for patients, caregivers, and health professionals. Balancing the allograft response and reducing toxicity associated with immunosuppression is essential to achieving optimal outcomes. Current immunosuppression usually includes a combination of induction therapies, such as T cell–depleting agents or IL-2 receptor antibodies, followed by a typical maintenance regimen of calcineurin inhibitors, antiproliferative agents, and corticosteroids.
Original languageEnglish
Pages (from-to)6-8
Number of pages3
JournalJournal of The American Society of Nephrology
Issue number1
Publication statusPublished - Jan 2020


  • Steroids
  • Kidney transplantation
  • Acute allograft rejection
  • Delayed graft function


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