TY - JOUR
T1 - Which health-related quality of life score? A comparison of alternative utility measures in patients with Type 2 diabetes in the ADVANCE trial
AU - Glasziou, Paul
AU - Alexander, Jan
AU - Beller, Elaine
AU - Clarke, Philip
AU - ADVANCE Collaborative Group
AU - Chalmers, John
AU - MacMahon, Stephen
AU - Cooper, Mark
AU - Ferrannini, Eleuterio
AU - Grobbee, Diederick
AU - Hamet, Pavel
AU - Harrap, Stephen
AU - Heller, Simon
AU - Lisheng, Liu
AU - Mancia, Giuseppe
AU - Marre, Michel
AU - Mogensen, Carl
AU - Neal, Bruce
AU - Yu Pan, Chang
AU - Patel, Anushka
AU - Poulter, Neil
AU - Rodgers, Anthony
AU - Williams, Bryan
AU - Woodward, Mark
AU - Collins, Rory
AU - Holman, Rury
AU - Sandercock, Peter
AU - Sleight, Peter
AU - Adams, Mark
AU - Branley, Michael
AU - Fulcher, Greg
AU - Jenkins, Bronwyn
AU - Louis, Damien
AU - Lou, Wei
AU - Lowe, Harry
AU - McCormack, Anne
AU - Mitchell, Paul
AU - Ong, Stephen
AU - Pollock, Carol
AU - Watson, John
AU - Wong, Tien
AU - Allen, Sarah
AU - Bompoint, Severine
AU - Carreras, Anna
AU - Chen, Tom
AU - Flynn, Samatha
AU - Gibb, Sophie
AU - Han, Dorothy
AU - Hough, Sally
AU - Jayne, Kathy
AU - Joshi, Roshina
AU - Kengne, Andrew Pascal
AU - Linn, Jennifer
AU - Monaghan, Helen
AU - Ng, Robyn
AU - Perkovic, Vlado
AU - Regaglia, Joanne
AU - Schmidt, Manuela
AU - Xin, Du
AU - Yufang, Bi
AU - Holloway, Terry
AU - Gray, Barry
AU - Milne, Amanda
AU - Adderkin, Alison
AU - Guertin, Marie Renee
AU - de Guise, Danielle
AU - Liyuan, Ma
AU - Reid, Jane
AU - Subramaniam, Ravathi
AU - Wen, Wang
AU - Williamson, Karin
N1 - Creative Commons Attribution information from this article:
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
PY - 2007/4/27
Y1 - 2007/4/27
N2 - Background: Diabetes has a high burden of illness both in life years lost and in disability through related co-morbidities. Accurate assessment of the non-mortality burden requires appropriate health-related quality of life and summary utility measures of which there are several contenders. The study aimed to measure the impact of diabetes on various health-related quality of life domains, and compare several summary utility measures. Methods: In the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation) study, 978 Australian patients with Type 2 diabetes completed two health-related quality of life questionnaires at baseline: the EQ-5D and the SF-36v2, from which nine summary utility measures were calculated, and compared. The algorithms were grouped into four classes: (i) based on the EQ-5D; (ii) using fewer items than those in the SF-12 (iii) using the items in the SF-12; and (iv) using all items of the SF-36. Results: Overall health-related quality of life of the subjects was good (mean utility ranged from 0.68 (±0.08) to 0.85(±0.14) over the nine utility measures) and comparable to patients without diabetes. Summary indices were well correlated with each other (r = 0.76 to 0.99), and showed lower health-related quality of life in patients with major diabetes-related events such as stroke or myocardial infarction. Despite the smaller number of items used in the scoring of the EQ-5D, it generally performed at least as well as SF-36 based methods. However, all utility measures had some limitation such as limited range or ceiling effects. Conclusion: The summary utility measures showed good agreement, and showed good discrimination between major and minor health state changes. However, EQ-5D based measures performed as well and are generally simpler to use.
AB - Background: Diabetes has a high burden of illness both in life years lost and in disability through related co-morbidities. Accurate assessment of the non-mortality burden requires appropriate health-related quality of life and summary utility measures of which there are several contenders. The study aimed to measure the impact of diabetes on various health-related quality of life domains, and compare several summary utility measures. Methods: In the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation) study, 978 Australian patients with Type 2 diabetes completed two health-related quality of life questionnaires at baseline: the EQ-5D and the SF-36v2, from which nine summary utility measures were calculated, and compared. The algorithms were grouped into four classes: (i) based on the EQ-5D; (ii) using fewer items than those in the SF-12 (iii) using the items in the SF-12; and (iv) using all items of the SF-36. Results: Overall health-related quality of life of the subjects was good (mean utility ranged from 0.68 (±0.08) to 0.85(±0.14) over the nine utility measures) and comparable to patients without diabetes. Summary indices were well correlated with each other (r = 0.76 to 0.99), and showed lower health-related quality of life in patients with major diabetes-related events such as stroke or myocardial infarction. Despite the smaller number of items used in the scoring of the EQ-5D, it generally performed at least as well as SF-36 based methods. However, all utility measures had some limitation such as limited range or ceiling effects. Conclusion: The summary utility measures showed good agreement, and showed good discrimination between major and minor health state changes. However, EQ-5D based measures performed as well and are generally simpler to use.
UR - http://www.scopus.com/inward/record.url?scp=34249665476&partnerID=8YFLogxK
M3 - Article
C2 - 17462100
AN - SCOPUS:34249665476
SN - 1477-7525
VL - 5
JO - Health and Quality of Life Outcomes
JF - Health and Quality of Life Outcomes
M1 - 21
ER -
