Who are at risk from familial colorectal cancer and how can they be managed?

Paul Rozen, Bernard Levin, Graeme P. Young

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Citations (Scopus)


How to ide~r~tifl’ individual!; and families at risk. for colii)rec:tal can•cer1' Asking a simple question, ‘has anyone had cancer in your family?', can quite easily identify these families. An affirmative answer leads to the follow-up questions, ‘Who has had cancer-parents, siblings or children (first-degree relatives); grandparents, grandcl1ildren, uncles, aunts (seconddegree r•9latives); cousins?; Wt1ere did these tu rnors occur-colon, breast, ovary, etc?, and ‘At what agH did these occur?'. If asking these simple questions becomes routine, t11en they are not time-consuming and can identify individuals and families at risk for common malignancies (Table 6.1). Answers that cause the p1ysician to suspect a familial risk factor include cancers occurring t1efore the age of 50-5~i years, several cancers occurring in the sam•9 individual and/or cancers occurring in two or more first or second-degree relatives. These ‘alarm’ answers demand a more detailed cancer pedigree (Figure 6.2a).

Original languageEnglish
Title of host publicationColorectal Cancer in Clinical Practice
Subtitle of host publicationPrevention, Early Detection and Management
EditorsPaul Rozen, Graeme P. Young, Bernard Levin, Stephen J. Spann
Place of PublicationBoca Raton, FL.
PublisherCRC Press/Balkema
Number of pages18
ISBN (Electronic)9781482207781
ISBN (Print)9781138455399
Publication statusPublished - 2006


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