Who does TORC2 talk to

Jianling Xie, Xuemin Wang, Christopher G. Proud

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The target of rapamycin (TOR) is a protein kinase that, by forming complexes with partner proteins, governs diverse cellular signalling networks to regulate a wide range of processes. TOR thus plays central roles in maintaining normal cellular functions and, when dysregulated, in diverse diseases. TOR forms two distinct types of multiprotein complexes (TOR complexes 1 and 2, TORC1 and TORC2). TORC1 and TORC2 differ in their composition, their control and their substrates, so that they play quite distinct roles in cellular physiology. Much effort has been focused on deciphering the detailed regulatory links within the TOR pathways and the structure and control of TOR complexes. In this review, we summarize recent advances in understanding mammalian (m) TORC2, its structure, its regulation, and its substrates, which link TORC2 signalling to the control of cell functions. It is now clear that TORC2 regulates several aspects of cell metabolism, including lipogenesis and glucose transport. It also regulates gene transcription, the cytoskeleton, and the activity of a subset of other protein kinases.

Original languageEnglish
Pages (from-to)1721-1738
Number of pages18
JournalBiochemical Journal
Volume475
Issue number10
DOIs
Publication statusPublished - 24 May 2018
Externally publishedYes

Fingerprint Dive into the research topics of 'Who does TORC2 talk to'. Together they form a unique fingerprint.

  • Cite this

    Xie, J., Wang, X., & Proud, C. G. (2018). Who does TORC2 talk to. Biochemical Journal, 475(10), 1721-1738. https://doi.org/10.1042/BCJ20180130