Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia

Ella M. Meumann; Nicholas M. Anstey; Bart J. Currie; Kim A. Piera; Robert Baird; Derek S. Sarovich; Joshua S. Davis

doi:10.1093/ofid/ofz263

Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia

Ella M. Meumann, Nicholas M. Anstey, Bart J. Currie, Kim A. Piera, Robert Baird, Derek S. Sarovich, Joshua S. Davis

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Abstract

Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3 56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

Original language	English
Article number	ofz263
Number of pages	4
Journal	Open Forum Infectious Diseases
Volume	6
Issue number	7
DOIs	https://doi.org/10.1093/ofid/ofz263
Publication status	Published - Jul 2019
Externally published	Yes

Keywords

Acinetobacter baumannii
Community-Acquired pneumonia
Recurrence
Relapse
Whole-genome sequencing.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ofid/ofz263Licence: CC BY-NC-ND

Published versionFinal published version, 157 KBLicence: CC BY-NC-ND

Cite this

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title = "Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia",

abstract = "Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3 56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.",

keywords = "Acinetobacter baumannii, Community-Acquired pneumonia, Recurrence, Relapse, Whole-genome sequencing.",

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year = "2019",

month = jul,

doi = "10.1093/ofid/ofz263",

language = "English",

volume = "6",

journal = "Open Forum Infectious Diseases",

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T1 - Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia

AU - Meumann, Ella M.

AU - Anstey, Nicholas M.

AU - Currie, Bart J.

AU - Piera, Kim A.

AU - Baird, Robert

AU - Sarovich, Derek S.

AU - Davis, Joshua S.

PY - 2019/7

Y1 - 2019/7

N2 - Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3 56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

AB - Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3 56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

KW - Acinetobacter baumannii

KW - Community-Acquired pneumonia

KW - Recurrence

KW - Relapse

KW - Whole-genome sequencing.

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UR - http://purl.org/au-research/grants/NHMRC/1114696

UR - http://purl.org/au-research/grants/NHMRC/1135820

UR - http://purl.org/au-research/grants/NHMRC/1160331

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DO - 10.1093/ofid/ofz263

M3 - Article

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SN - 2328-8957

VL - 6

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 7

M1 - ofz263

ER -

Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia

Abstract

Keywords

UN SDGs

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