Why does clozapine cause increased rebound psychosis and catatonia, compared to quetiapine?

Tarun Bastiampillai, Wini Wei Lam Woo, Sherry Kit Wa Chan, Pramod C. Nair

    Research output: Contribution to journalLetterpeer-review

    Abstract

    To the Editor

    Quetiapine was synthesised as a clozapine mimetic (Monahan et al., 2020), also sharing similar pharmacodynamic characteristics to that of clozapine, rapidly dissociating from the D2 receptor (Lander et al., 2018; Nair et al., 2020). Clozapine has the highest propensity among all antipsychotic medications (including quetiapine) in leading to rebound psychosis and catatonia (occurring less than 1 week following cessation of the antipsychotic), in addition to other discontinuation-related symptoms...
    Original languageEnglish
    Number of pages1
    JournalAustralian and New Zealand Journal of Psychiatry
    Early online date10 May 2021
    DOIs
    Publication statusE-pub ahead of print - 10 May 2021

    Keywords

    • clozapine
    • antipsychotic medications
    • withdrawal
    • psychosis
    • catatonia

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