WISKOTT‐ALDRICH SYNDROME IN IDENTICAL TWINS: ABNORMALITY OF CD4 AND CD8 POSITIVE LYMPHOCYTES

K. FORSYTH, R. SESHADRI, C. MATTHEWS, R. HEDDLE

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The rare occurrence of Wiskott‐Aldrich syndrome (WAS) in identical twin brothers without a preceding family history of the disease is described. Investigation into the nature of the lymphocyte abnormality in the surviving twin suggests that the frequency of T cell clone forming cells is markedly decreased. Further analysis of the T cell clones showed a deficiency of CD8 positive cytotoxic/suppressor cells. This alteration may be an underlying mechanism in the development of some of the clinical manifestations of WAS

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalAustralian and New Zealand Journal of Medicine
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 1988
Externally publishedYes

Keywords

  • CD4 positive cell
  • CD8 positive cell
  • cytotoxic T cell
  • infection
  • suppressor T cell
  • T cell
  • T cell clone
  • Wiskott‐Aldrich syndrome

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