WISKOTT‐ALDRICH SYNDROME IN IDENTICAL TWINS: ABNORMALITY OF CD4 AND CD8 POSITIVE LYMPHOCYTES

K. FORSYTH; R. SESHADRI; C. MATTHEWS; R. HEDDLE

doi:10.1111/j.1445-5994.1988.tb02247.x

WISKOTT‐ALDRICH SYNDROME IN IDENTICAL TWINS: ABNORMALITY OF CD4 AND CD8 POSITIVE LYMPHOCYTES

K. FORSYTH
, R. SESHADRI
, C. MATTHEWS
, R. HEDDLE

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The rare occurrence of Wiskott‐Aldrich syndrome (WAS) in identical twin brothers without a preceding family history of the disease is described. Investigation into the nature of the lymphocyte abnormality in the surviving twin suggests that the frequency of T cell clone forming cells is markedly decreased. Further analysis of the T cell clones showed a deficiency of CD8 positive cytotoxic/suppressor cells. This alteration may be an underlying mechanism in the development of some of the clinical manifestations of WAS

Original language	English
Pages (from-to)	73-76
Number of pages	4
Journal	Australian and New Zealand Journal of Medicine
Volume	18
Issue number	1
DOIs	https://doi.org/10.1111/j.1445-5994.1988.tb02247.x
Publication status	Published - Feb 1988
Externally published	Yes

Keywords

CD4 positive cell
CD8 positive cell
cytotoxic T cell
infection
suppressor T cell
T cell
T cell clone
Wiskott‐Aldrich syndrome

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title = "WISKOTT‐ALDRICH SYNDROME IN IDENTICAL TWINS: ABNORMALITY OF CD4 AND CD8 POSITIVE LYMPHOCYTES",

abstract = "The rare occurrence of Wiskott‐Aldrich syndrome (WAS) in identical twin brothers without a preceding family history of the disease is described. Investigation into the nature of the lymphocyte abnormality in the surviving twin suggests that the frequency of T cell clone forming cells is markedly decreased. Further analysis of the T cell clones showed a deficiency of CD8 positive cytotoxic/suppressor cells. This alteration may be an underlying mechanism in the development of some of the clinical manifestations of WAS",

keywords = "CD4 positive cell, CD8 positive cell, cytotoxic T cell, infection, suppressor T cell, T cell, T cell clone, Wiskott‐Aldrich syndrome",

author = "K. FORSYTH and R. SESHADRI and C. MATTHEWS and R. HEDDLE",

year = "1988",

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doi = "10.1111/j.1445-5994.1988.tb02247.x",

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T2 - ABNORMALITY OF CD4 AND CD8 POSITIVE LYMPHOCYTES

AU - FORSYTH, K.

AU - SESHADRI, R.

AU - MATTHEWS, C.

AU - HEDDLE, R.

PY - 1988/2

Y1 - 1988/2

N2 - The rare occurrence of Wiskott‐Aldrich syndrome (WAS) in identical twin brothers without a preceding family history of the disease is described. Investigation into the nature of the lymphocyte abnormality in the surviving twin suggests that the frequency of T cell clone forming cells is markedly decreased. Further analysis of the T cell clones showed a deficiency of CD8 positive cytotoxic/suppressor cells. This alteration may be an underlying mechanism in the development of some of the clinical manifestations of WAS

AB - The rare occurrence of Wiskott‐Aldrich syndrome (WAS) in identical twin brothers without a preceding family history of the disease is described. Investigation into the nature of the lymphocyte abnormality in the surviving twin suggests that the frequency of T cell clone forming cells is markedly decreased. Further analysis of the T cell clones showed a deficiency of CD8 positive cytotoxic/suppressor cells. This alteration may be an underlying mechanism in the development of some of the clinical manifestations of WAS

KW - CD4 positive cell

KW - CD8 positive cell

KW - cytotoxic T cell

KW - infection

KW - suppressor T cell

KW - T cell

KW - T cell clone

KW - Wiskott‐Aldrich syndrome

UR - https://www.scopus.com/pages/publications/0023878763

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SN - 0004-8291

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SP - 73

EP - 76

JO - Australian and New Zealand Journal of Medicine

JF - Australian and New Zealand Journal of Medicine

IS - 1

ER -

WISKOTT‐ALDRICH SYNDROME IN IDENTICAL TWINS: ABNORMALITY OF CD4 AND CD8 POSITIVE LYMPHOCYTES

Abstract

Keywords

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