Young-Onset Cancers—Early Steps in the Right Direction

The global incidence of young-onset (YO) cancer is on the rise. Determining the cause of this disturbing trend has been listed as one of the Grand Cancer Challenges [1]. The incidence of YO cancers in the gastrointestinal tract are on the rise in the past two to three decades, in the United States, with YO colorectal cancer increasing across the world [2].To note, incidence rates of some countries may be partly due to the lack of a strict cancer registry of every documented case, and, therefore, while there is a lot of work to be done to address the problem, the first steps include advocacy and the need to encourage reporting of the burden of the problem. This may help identify trends that could guide focused research into the etiology. This Special Issue hosted by Cancers entitled “Young-onset GI(gastrointestinal) cancer” presented clinicians and researchers around the world with a platform to submit their research focused on YO cancer.