TY - JOUR
T1 - ZBTB1 is a determinant of lymphoid development
AU - Siggs, Owen M.
AU - Li, Xiaohong
AU - Xia, Yu
AU - Beutler, Bruce
N1 - This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
PY - 2012
Y1 - 2012
N2 - In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.
AB - In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.
UR - http://www.scopus.com/inward/record.url?scp=84863115210&partnerID=8YFLogxK
U2 - 10.1084/jem.20112084
DO - 10.1084/jem.20112084
M3 - Article
C2 - 22201126
AN - SCOPUS:84863115210
SN - 0022-1007
VL - 209
SP - 19
EP - 27
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 1
ER -