Zinc-fortified oral rehydration solution improved intestinal permeability and small intestinal mucosal recovery.

Cuong Tran, Joanna Hawkes, Robin Graham, Julie Kitchen, Erin Symonds, Geoffrey Davidson, Ross Butler

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    11 Citations (Scopus)

    Abstract

    A randomized double-blind placebo-controlled study was conducted in children admitted to hospital with gastroenteritis (≥3 loose stools per day). All were treated for 5 days following admission with either zinc (Zn, 3 mg) or without Zn-fortified rice-based oral rehydration solution (ORS). 13C-sucrose breath test (SBT) and intestinal permeability (lactulose/rhamnose or L/R ratio) were performed concurrently prior to commencement of ORS with or without Zn and at day 5 post-admission. There was a significant improvement in the SBT results in both the Zn-fortified group, median (5th-95th percentile) 2.1% (0.4% to 8.3%) versus 4.4% (0.4% to 10.4%), P <.05, and control group, 1.4% (0.1% to 5.4%) versus 4.3% (0.4% to 11.4%), P <.05, between the day of admission and day 5 post-admission. In the Zn-fortified group, there was also a significant improvement in L/R ratio between the day of admission and day 5 post-admission, 53.0 (19.5-90.6) versus 17.7 (13.4-83.2), P <.05. Low levels of Zn improved intestinal permeability but did not enhance short-term recovery following diarrheal illness.

    Original languageEnglish
    Pages (from-to)676-682
    Number of pages7
    JournalCLINICAL PEDIATRICS
    Volume54
    Issue number7
    DOIs
    Publication statusPublished - 4 Jun 2015

    Keywords

    • diarrheal disease
    • intestinal permeability
    • sucrose breath test
    • zinc-fortified oral rehydration solution

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