A biclonal case of chronic lymphocytic leukaemia with discordant mutational status of the immunoglobulin heavy chain variable region and bimodal CD49d expression

Anya K. Hotinski,; Oliver G. Best; Lauren A. Thurgood,; Karen M. Lower; Bryone J. Kuss

doi:10.1111/bjh.17257

A biclonal case of chronic lymphocytic leukaemia with discordant mutational status of the immunoglobulin heavy chain variable region and bimodal CD49d expression

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

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Abstract

An 87-year-old man with multiple medical comorbidities presented to the haematology clinic in April of 2013 with a six-month history of anorexia, weight loss, progressive anaemia and lymphocytosis. On examination, splenomegaly and small volume widespread lymphadenopathy was observed. The initial blood results showed...

Original language	English
Pages (from-to)	e77-e81
Number of pages	4
Journal	British Journal of Haematology
Volume	192
Issue number	3
Early online date	5 Dec 2020
DOIs	https://doi.org/10.1111/bjh.17257
Publication status	Published - Feb 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CLL
clonal architecture
IGHV
trisomy 12
whole-exome sequencing

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10.1111/bjh.17257Licence: In Copyright

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abstract = "An 87-year-old man with multiple medical comorbidities presented to the haematology clinic in April of 2013 with a six-month history of anorexia, weight loss, progressive anaemia and lymphocytosis. On examination, splenomegaly and small volume widespread lymphadenopathy was observed. The initial blood results showed... ",

keywords = "CLL, clonal architecture, IGHV, trisomy 12, whole-exome sequencing",

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AU - Best, Oliver G.

AU - Thurgood,, Lauren A.

AU - Lower, Karen M.

AU - Kuss, Bryone J.

PY - 2021/2

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AB - An 87-year-old man with multiple medical comorbidities presented to the haematology clinic in April of 2013 with a six-month history of anorexia, weight loss, progressive anaemia and lymphocytosis. On examination, splenomegaly and small volume widespread lymphadenopathy was observed. The initial blood results showed...

KW - CLL

KW - clonal architecture

KW - IGHV

KW - trisomy 12

KW - whole-exome sequencing

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A biclonal case of chronic lymphocytic leukaemia with discordant mutational status of the immunoglobulin heavy chain variable region and bimodal CD49d expression

Abstract

UN SDGs

Keywords

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